PDB entry 5o4g

View 5o4g on RCSB PDB site
Description: HER2 in complex with Fab MF3958
Class: oncoprotein
Keywords: HER2 ectodomain, complex, Fab, transferase, oncoprotein
Deposited on 2017-05-29, released 2018-05-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MF3958 FAB light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5O4G (0-213)
    Domains in SCOPe 2.08: d5o4ga1, d5o4ga2
  • Chain 'B':
    Compound: MF3958 FAB heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5O4G
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, MLN19, NEU, NGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5o4gc1, d5o4gc2, d5o4gc3
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5o4gA (A:)
diqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapklliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystpptfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5o4gC (C:)
tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
cqpcpi

    Sequence, based on observed residues (ATOM records): (download) 
    >5o4gC (C:)
tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
yvliahnqvrqvplqrlrivrgtqlfednyalavldngdpgglrelqlrslteilkggvl
iqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessedcqs
ltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpalvty
ntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrcekc
skpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplqp
eqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlg
lrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachql
carghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpch