PDB entry 5o4g

View 5o4g on RCSB PDB site
Description: HER2 in complex with Fab MF3958
Class: oncoprotein
Keywords: HER2 ectodomain, complex, Fab, transferase, oncoprotein
Deposited on 2017-05-29, released 2018-05-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MF3958 FAB light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5O4G (0-213)
    Domains in SCOPe 2.07: d5o4ga1, d5o4ga2
  • Chain 'B':
    Compound: MF3958 FAB heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5O4G
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, MLN19, NEU, NGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5o4gc1, d5o4gc2, d5o4gc3
  • Heterogens: NAG, BMA, MAN

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5o4gA (A:)
    diqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfatyycqqsystpptfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5o4gC (C:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelql
    rslteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgs
    rcwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsg
    icelhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqev
    taedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfd
    gdpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngays
    ltlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrped
    ecvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclp
    chpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeega
    cqpcpi
    

    Sequence, based on observed residues (ATOM records): (download)
    >5o4gC (C:)
    tqvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqg
    yvliahnqvrqvplqrlrivrgtqlfednyalavldngdpgglrelqlrslteilkggvl
    iqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessedcqs
    ltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpalvty
    ntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrcekc
    skpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplqp
    eqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlg
    lrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachql
    carghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpch