PDB entry 5o1a
View 5o1a on RCSB PDB site
Description: p53 cancer mutant Y220C in complex with compound MB240
Class: DNA binding protein
Keywords: p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, DNA binding protein, molecular chaperones
Deposited on
2017-05-18, released
2018-05-09
The last revision prior to the SCOPe 2.07 freeze date was dated
2018-05-09, with a file datestamp of
2018-05-04.
Experiment type: XRAY
Resolution: 1.44 Å
R-factor: N/A
AEROSPACI score: 0.51
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: TP53, P53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.07: d5o1aa_ - Chain 'B':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: TP53, P53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.07: d5o1ab_ - Heterogens: ZN, 9H5, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5o1aA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>5o1aA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhs
vvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvc
acpgrdrrteeenlrk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5o1aB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>5o1aB (B:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrh
svvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrv
cacpgrdrrteeenlr