PDB entry 5nx9

View 5nx9 on RCSB PDB site
Description: Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL) in complex with its products AMP and fumarate
Class: lyase
Keywords: Adenylosuccinate Lyase, fumarase, lyase
Deposited on 2017-05-09, released 2018-05-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-30, with a file datestamp of 2018-05-25.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens neanderthalensis [TaxId:63221]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NX9
    Domains in SCOPe 2.07: d5nx9a_
  • Chain 'B':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens neanderthalensis [TaxId:63221]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NX9
    Domains in SCOPe 2.07: d5nx9b_
  • Chain 'C':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens neanderthalensis [TaxId:63221]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NX9
    Domains in SCOPe 2.07: d5nx9c_
  • Chain 'D':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens neanderthalensis [TaxId:63221]
    Database cross-references and differences (RAF-indexed):
    • PDB 5NX9 (Start-486)
    Domains in SCOPe 2.07: d5nx9d_
  • Heterogens: CL, AMP, FUM, PEG, 2SA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nx9A (A:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqadayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >5nx9A (A:)
spdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqemksn
lenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrnal
dlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlkr
vrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkvd
ievlsvlaslgasvhkictdirllanlkemeepfekqqigkrnpmrserccslarhlmtl
vmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrir
qelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqadayfs
pihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmkvka

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5nx9B (B:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqadayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >5nx9B (B:)
gspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqemks
nlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrna
ldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlk
rvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkv
dievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrnpmrserccsl
arhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypk
vierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieri
qadayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmkvkaelc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5nx9C (C:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqadayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >5nx9C (C:)
spdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqemksn
lenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrnal
dlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlkr
vrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkvd
ievlsvlaslgasvhkictdirllanlkemeeprnpmrserccslarhlmtlvmdplqta
svqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirqelpfmat
eniimamvhekirvlsqqaasvvkqeggdndlieriqadayfspihsqldhlldpssftg
rasqqvqrfleeevypllkpy

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5nx9D (D:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiqemksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqadayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >5nx9D (D:)
gspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiqemks
nlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrna
ldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlk
rvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkv
dievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrnpmrserccsl
arhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypk
vierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieri
qadayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmkvkaelcl