PDB entry 5nuh

View 5nuh on RCSB PDB site
Description: Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain
Class: transferase
Keywords: SIV, Virus, Nef, SH3, TRANSFERASE
Deposited on 2017-04-30, released 2017-08-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein Nef
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: nef
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nuha_
  • Chain 'B':
    Compound: Protein Nef
    Species: Simian immunodeficiency virus [TaxId:11723]
    Gene: nef
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nuhb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Gene: HCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08631 (Start-12)
      • linker (13-16)
    • Uniprot P08631 (17-End)
    Domains in SCOPe 2.08: d5nuhc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Gene: HCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08631 (Start-12)
      • linker (13-16)
    • Uniprot P08631 (17-End)
    Domains in SCOPe 2.08: d5nuhd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nuhA (A:)
gamatpwrnpaeereklayrkqnmddideedddlvgvsvrpkvplrtmsyklaidmshfi
kekgglegiyysarrhrildiylekeegiipdwqdytsgpgirypktfgwlwklvpvnvs
deaqedeehylmhpaqtsqwddpwgevlawkfdptlaytyeayvrypeefgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5nuhA (A:)
rpkvplrtmsyklaidmshfikekgglegiyysarrhrildiylekeegiipdwqdytsg
pgirypktfgwlwklvpvnvedeehylmhpaqtsqwddpwgevlawkfdptlaytyeayv
rypeef

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5nuhB (B:)
gamatpwrnpaeereklayrkqnmddideedddlvgvsvrpkvplrtmsyklaidmshfi
kekgglegiyysarrhrildiylekeegiipdwqdytsgpgirypktfgwlwklvpvnvs
deaqedeehylmhpaqtsqwddpwgevlawkfdptlaytyeayvrypeefgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5nuhB (B:)
rpkvplrtmsyklaidmshfikekgglegiyysarrhrildiylekeegiipdwqdytsg
pgirypktfgwlwklvpvnvsdeaqedeehylmhpaqtsqwddpwgevlawkfdptlayt
yeayvrypeef

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5nuhC (C:)
mediivvalydyegwwgdlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvds

    Sequence, based on observed residues (ATOM records): (download) 
    >5nuhC (C:)
iivvalydyegwwgdlsfqkgdqmvvleesgewwkarslatrkegyipsnyvar

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5nuhD (D:)
mediivvalydyegwwgdlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvds

    Sequence, based on observed residues (ATOM records): (download) 
    >5nuhD (D:)
diivvalydyegwwgdlsfqkgdqmvvleesgewwkarslatrkegyipsnyvar