PDB entry 5n47

View 5n47 on RCSB PDB site
Description: Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin
Class: protein binding
Keywords: lipocalin, anticalin, lipocalin-based binding protein, protein binding, human fibronectin, oncofetal splice variant, fn type III domain, extra-domain b, eiiib, ed-b, extracellular matrix, structural protein
Deposited on 2017-02-10, released 2018-02-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-03-21, with a file datestamp of 2018-03-16.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188 (Start-177)
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (99)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (133)
      • expression tag (178-181)
    Domains in SCOPe 2.07: d5n47a1, d5n47a2
  • Chain 'B':
    Compound: Fibronectin
    Species: Homo sapiens [TaxId:9606]
    Gene: FN1, FN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02751 (Start-275)
      • expression tag (276)
  • Chain 'C':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (99)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (133)
    Domains in SCOPe 2.07: d5n47c_
  • Chain 'D':
    Compound: Fibronectin
    Species: Homo sapiens [TaxId:9606]
    Gene: FN1, FN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02751 (0-275)
      • expression tag (276-279)
  • Chain 'E':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: LCN2, HNL, NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (99)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (133)
    Domains in SCOPe 2.07: d5n47e_
  • Chain 'F':
    Compound: Fibronectin
    Species: Homo sapiens [TaxId:9606]
    Gene: FN1, FN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02751 (0-275)
      • expression tag (276)

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5n47A (A:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvgeagnsllredkdprkmyatiyelke
dksynvtsvrfrskkchylirtfvpgsqpgeftlglikskpghtsflvrvvstnynqham
vffktvaqnreyffitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
wshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >5n47A (A:)
stsdlipapplskvplqqnfqdnqfhgkwyvvgeagnsllredkdprkmyatiyelkedk
synvtsvrfrskkchylirtfvpgsqpgeftlglikskpghtsflvrvvstnynqhamvf
fktvaqnreyffitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsaws

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5n47C (C:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvgeagnsllredkdprkmyatiyelke
dksynvtsvrfrskkchylirtfvpgsqpgeftlglikskpghtsflvrvvstnynqham
vffktvaqnreyffitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
wshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >5n47C (C:)
dstsdlipapplskvplqqnfqdnqfhgkwyvvgeagnsllredkdprkmyatiyelked
ksynvtsvrfrskkchylirtfvpgsqpgeftlglikskpghtsflvrvvstnynqhamv
ffktvaqnreyffitlygrtkeltselkenfirfskslglpenhivfpvpidqcid

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5n47E (E:)
qdstsdlipapplskvplqqnfqdnqfhgkwyvvgeagnsllredkdprkmyatiyelke
dksynvtsvrfrskkchylirtfvpgsqpgeftlglikskpghtsflvrvvstnynqham
vffktvaqnreyffitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
wshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >5n47E (E:)
dlipapplskvplqqnfqdnqfhgkwyvvgeagnsllredkdprkmyatiyelkedksyn
vtsvrfrskkchylirtfvpgsqpgeftlglikskpghtsflvrvvstnynqhamvffkt
vaqnreyffitlygrtkeltselkenfirfskslglpenhivfpvpidqcid

  • Chain 'F':
    No sequence available.