PDB entry 5n0z

View 5n0z on RCSB PDB site
Description: hPAD4 crystal complex with AFM-41a
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-02-03, released 2017-05-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-05-24, with a file datestamp of 2017-05-19.
Experiment type: XRAY
Resolution: 2.52 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein-arginine deiminase type-4
    Species: Homo sapiens [TaxId:9606]
    Gene: PADI4, PAD4, PADI5, PDI5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM07 (Start-669)
      • engineered mutation (88)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d5n0za1, d5n0za2, d5n0za3
  • Heterogens: SO4, CA, 8FT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5n0zA (A:)
gplgspqmaqgtlirvtpeqpthavcvlgtltqldicssapedctsfsinaspgvvvdia
hsppakkkstgsstwpldpgvevtltmkaasgstgdqkvqisyygpktppvkallyltav
eislcaditrtgkvkptravkdqrtwtwgpcgqgaillvncdrdnlessamdceddevld
sedlqdmslmtlstktpkdfftnhtlvlhvarsemdkvrvfqatrgklsskcsvvlgpkw
pshylmvpggkhnmdfyvealafpdtdfpglitltislldtsnlelpeavvfqdsvvfrv
apwimtpntqppqevyacsifenedflksvttlamkakcklticpeeenmddqwmqdeme
igyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgpqtggisgldsfgnlevs
ppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqvqapvklysdwlsvghvd
eflsfvpapdrkgfrlllasprscyklfqeqqneghgeallfegikkkkqqkiknilsnk
tlrehnsfvercidwnrellkrelglaesdiidipqlfklkefskaeaffpnmvnmlvlg
khlgipkpfgpvingrccleekvcslleplglqctfindfftyhirhgevhcgtnvrrkp
fsfkwwnmvp

    Sequence, based on observed residues (ATOM records): (download) 
    >5n0zA (A:)
qgtlirvtpeqpthavcvlgtltqldicssapedctsfsinaspgvvvdiahstwpldpg
vevtltmkaasgstgdqkvqisyygpktppvkallyltaveislcaditrtgkvkdqrtw
twgpcgqgaillvncdrdnlessamdceddevldsedlqdmslmtlstktpkdfftnhtl
vlhvarsemdkvrvfqatkcsvvlgpkwpshylmvpggkhnmdfyvealafpdtdfpgli
tltislldtsnlelpeavvfqdsvvfrvapwimtpntqppqevyacsifenedflksvtt
lamkakcklticpeeenmddqwmqdemeigyiqaphktlpvvfdsprnrglkefpikrvm
gpdfgyvtrgpqtggisgldsfgnlevsppvtvrgkeyplgrilfgdscypsndsrqmhq
alqdflsaqqvqapvklysdwlsvghvdeflsfvpapdrkgfrlllasprscyklfqeqq
neghgeallfegikkkkqqkiknilsnktlrehnsfvercidwnrellkrelglaesdii
dipqlfklkefskaeaffpnmvnmlvlgkhlgipkpfgpvingrccleekvcslleplgl
qctfindfftyhirhgevhcgtnvrrkpfsfkwwnmvp