PDB entry 5my6

View 5my6 on RCSB PDB site
Description: Crystal structure of a HER2-Nb complex
Class: transferase
Keywords: Nanobody, Her2, EGFR family, radio-labeling, transferase
Deposited on 2017-01-25, released 2017-08-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB2, HER2, MLN19, NEU, NGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5my6a1, d5my6a2, d5my6a3
  • Chain 'B':
    Compound: Nanobody 2Rs15d
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 5MY6 (0-114)
    Domains in SCOPe 2.07: d5my6b1, d5my6b2
  • Heterogens: NAG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5my6A (A:)
    qvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqgy
    vliahnqvrqvplqrlrivrgtqlfednyalavldngdplnnttpvtgaspgglrelqlr
    slteilkggvliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsr
    cwgessedcqsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgi
    celhcpalvtyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevt
    aedgtqrcekcskpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdg
    dpasntaplqpeqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysl
    tlqglgiswlglrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpede
    cvgeglachqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpc
    hpecqpqngsvtcfgpeadqcvacahykdppfcvarcpsgvkpdlsympiwkfpdeegac
    qpcpincthscvdlddkgcpae
    

    Sequence, based on observed residues (ATOM records): (download)
    >5my6A (A:)
    qvctgtdmklrlpaspethldmlrhlyqgcqvvqgnleltylptnaslsflqdiqevqgy
    vliahnqvrqvplqrlrivrgtqlfednyalavldngdpaspgglrelqlrslteilkgg
    vliqrnpqlcyqdtilwkdifhknnqlaltlidtnrsrachpcspmckgsrcwgessedc
    qsltrtvcaggcarckgplptdccheqcaagctgpkhsdclaclhfnhsgicelhcpalv
    tyntdtfesmpnpegrytfgascvtacpynylstdvgsctlvcplhnqevtaedgtqrce
    kcpcarvcyglgmehlrevravtsaniqefagckkifgslaflpesfdgdpasntaplqp
    eqlqvfetleeitgylyisawpdslpdlsvfqnlqvirgrilhngaysltlqglgiswlg
    lrslrelgsglalihhnthlcfvhtvpwdqlfrnphqallhtanrpedecvgeglachql
    carghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpqngsv
    tcfgpeadqcvacfcv
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5my6B (B:)
    qvqlqesgggsvqaggslkltcaasgyifnscgmgwyrqspgrerelvsrisgdgdtwhk
    esvkgrftisqdnvkktlylqmnslkpedtavyfcavcynletywgqgtqvtvss