PDB entry 5mwp

View 5mwp on RCSB PDB site
Description: The structure of MR in complex with AZD9977.
Class: signaling protein
Keywords: Signaling protein, Nuclear Hormone receptor, ligand complex, peptide complex
Deposited on 2017-01-19, released 2018-03-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-07, with a file datestamp of 2018-03-02.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235 (Start-271)
      • expression tag (18-19)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d5mwpa1, d5mwpa2
  • Chain 'B':
    Compound: NCOA1 peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5MWP (Start-14)
  • Heterogens: ECV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5mwpA (A:)
mhnhnhnhnhnhnggenlyfqgtpspvmvleniepeivyagydsskpdtaenllstlnrl
agkqmiqvvkwakvlpgfknlpledqitliqyswmslssfalswrsykhtnsqflyfapd
lvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaaf
eemrtnyikelrkmvtkspnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshal
kvefpamlveiisdqlpkvesgnakplyfhrkggslvprgsgggsggsggpqaqqksllq
qllte

    Sequence, based on observed residues (ATOM records): (download) 
    >5mwpA (A:)
yfspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlp
ledqitliqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhq
islqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtkswqrf
yqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyf
hrk

  • Chain 'B':
    No sequence available.