PDB entry 5mvd

View 5mvd on RCSB PDB site
Description: Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Class: oxidoreductase
Keywords: dhodh, human dhodh, OXIDOREDUCTASE
Deposited on 2017-01-16, released 2017-03-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5mvda_
  • Heterogens: FMN, ORO, U91, ACT, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5mvdA (A:)
    derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
    iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
    lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
    sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
    elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
    ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
    hrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5mvdA (A:)
    derfyaehlmptlqglldpesahrlavrftslgllpdsdmlevrvlghkfrnpvgiaagf
    dkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshglsvve
    hrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvsspka
    elrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtnttvs
    rpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdalekira
    gaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr