PDB entry 5mvc

View 5mvc on RCSB PDB site
Description: Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Class: oxidoreductase
Keywords: dhodh, human dhodh, Oxidoreductase
Deposited on 2017-01-16, released 2017-03-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5mvca_
  • Heterogens: FMN, ORO, Y9B, ACT, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5mvcA (A:)
    mghhhhhhhhhhssghiddddkhmatgderfyaehlmptlqglldpesahrlavrftslg
    llprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsvtpkpq
    egnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvnlgknk
    tsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqerdglrr
    vhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrsetgglsg
    kplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltfwgppv
    vgkvkreleallkeqgfggvtdaigadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5mvcA (A:)
    tgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgi
    aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
    svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvs
    spkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtn
    ttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdale
    kiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr