PDB entry 5mut

View 5mut on RCSB PDB site
Description: Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Class: oxidoreductase
Keywords: dhodh, human dhodh, oxidoreductase
Deposited on 2017-01-14, released 2017-03-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5muta_
  • Heterogens: FMN, ORO, HYT, ACT, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5mutA (A:)
tgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasv
vkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpii
gvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaig
adhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >5mutA (A:)
tgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgi
aagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgl
svvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvg
kaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidglivtntt
vsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqdaleki
ragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr