PDB entry 5mro

View 5mro on RCSB PDB site
Description: Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (1)
Class: transferase
Keywords: herbicide, anti-infectives, drug discovery, allosteric inhibition, mutant, transferase
Deposited on 2016-12-23, released 2017-07-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase, chloroplastic
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: ISPD, MCT, MECT, MEPCT, At2g02500, T8K22.20
    Database cross-references and differences (RAF-indexed):
    • Uniprot P69834 (1-End)
      • conflict (74)
      • engineered mutation (183)
    Domains in SCOPe 2.08: d5mroa_
  • Heterogens: Q9P, TRS, ACT, K, CD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5mroA (A:)
meksvsvillaggqgkrmkmsmpkqyipllgqpialysfftfsrmpevkeivvvcdpffr
difeeyeesidvdlsfaipgkerqdsvysglqeidvnselvcihdsarplvntedvekvl
kdgsavgaavlgvpakatikevnsdslvvktldrktlwemqtpqvikpellkkgfelvks
eglavtddvsiveylkhpvyvsqgsytnikvttpddlllaerilseds

    Sequence, based on observed residues (ATOM records): (download) 
    >5mroA (A:)
eksvsvillagmpkqyipllgqpialysfftfsrmpevkeivvvcdpffrdifeeyeesi
dvdlsfaipgkerqdsvysglqeidvnselvcihdsarplvntedvekvlkdgsavgaav
lgvpakatikevnsdslvvktldrktlwemqtpqvikpellkkgfelvkseglavtddvs
iveylkhpvyvsqgsytnikvttpddlllaerils