PDB entry 5mo4

View 5mo4 on RCSB PDB site
Description: ABL1 kinase (T334I_D382N) in complex with asciminib and nilotinib
Class: transferase
Keywords: Kinase, drug, inhibitor, transferase
Deposited on 2016-12-13, released 2017-04-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-04-12, with a file datestamp of 2017-04-07.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1, ABL, JTK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00519
      • conflict (294)
      • conflict (342)
    Domains in SCOPe 2.07: d5mo4a1, d5mo4a2, d5mo4a3
  • Heterogens: NIL, AY7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5mo4A (A:)
    gamdpsealqrpvasdfepqglseaarwnskenllagpsendpnlfvalydfvasgdntl
    sitkgeklrvlgynhngewceaqtkngqgwvpsnyitpvnslekhswyhgpvsrnaaeyl
    lssgingsflvresesspgqrsislryegrvyhyrintasdgklyvssesrfntlaelvh
    hhstvadglittlhypapkrnkptvygvspnydkwemertditmkhklgggqygevyegv
    wkkysltvavktlkedtmeveeflkeaavmkeikhpnlvqllgvctreppfyiiiefmty
    gnlldylrecnrqevnavvllymatqissameylekknfihrnlaarnclvgenhlvkva
    dfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvwafgvllweiatygmspy
    pgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaeihqafetmfqes
    sisdevekelgkqgv
    

    Sequence, based on observed residues (ATOM records): (download)
    >5mo4A (A:)
    nlfvalydfvasgdntlsitkgeklrvlgynhngewceaqtkngqgwvpsnyitpvnsle
    khswyhgpvsrnaaeyllssgingsflvresesspgqrsislryegrvyhyrintasdgk
    lyvssesrfntlaelvhhhstvadglittlhypapkrnkptvygvspnydkwemertdit
    mkhklgggqygevyegvwkkysltvavktlkedeveeflkeaavmkeikhpnlvqllgvc
    treppfyiiiefmtygnlldylrecnrqevnavvllymatqissameylekknfihrnla
    arnclvgenhlvkvadffpikwtapeslaynkfsiksdvwafgvllweiatygmspypgi
    dlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaeihqafetmfqessis
    devekelgk