PDB entry 5mj6

View 5mj6 on RCSB PDB site
Description: Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.
Class: hydrolase
Keywords: Insulin-regulated aminopeptidase, Endoplasmatic Reticulum Aminopeptidases, generation of antigenic peptides for cross-presentation, phosphinic pseudotripeptides, ligand-induced conformational changes, Hydrolase
Deposited on 2016-11-30, released 2017-04-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-04-26, with a file datestamp of 2017-04-21.
Experiment type: XRAY
Resolution: 2.53 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucyl-cystinyl aminopeptidase
    Species: Homo sapiens [TaxId:9606]
    Gene: LNPEP, OTASE
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIQ6 (Start-870)
      • expression tag (871-880)
    Domains in SCOPe 2.07: d5mj6a1, d5mj6a2, d5mj6a3, d5mj6a4, d5mj6a5
  • Chain 'B':
    Compound: Leucyl-cystinyl aminopeptidase
    Species: Homo sapiens [TaxId:9606]
    Gene: LNPEP, OTASE
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIQ6 (Start-870)
      • expression tag (871-880)
    Domains in SCOPe 2.07: d5mj6b1, d5mj6b2, d5mj6b3, d5mj6b4, d5mj6b5
  • Heterogens: NAG, BMA, MAN, ZN, 7O2, BR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5mj6A (A:)
atngklfpwaqirlptavvplryelslhpnltsmtfrgsvtisvqalqvtwniilhstgh
nisrvtfmsavssqekqaeileyayhgqiaivapeallaghnytlkieysanisssyygf
ygfsytdesnekkyfaatqfeplaarsafpcfdepafkatfiikiirdeqytalsnmpkk
ssvvlddglvqdefsesvkmstylvafivgemknlsqdvngtlvsiyavpekigqvhyal
ettvklleffqnyfeiqyplkkldlvaipdfeagamenwglltfreetllydsntssmad
rklvtkiiahelahqwfgnlvtmkwwndlwlnegfatfmeyfslekifkelssyedflda
rfktmkkdslnsshpisssvqsseqieemfdslsyfkgsslllmlktylsedvfqhavvl
ylhnhsyasiqsddlwdsfnevtnqtldvkrmmktwtlqkgfplvtvqkkgkelfiqqer
fflnmkpeiqpsdtsylwhiplsyvtegrnyskyqsvslldkksgvinlteevlwvkvni
nmngyyivhyadddwealihqlkinpyvlsdkdranlinnifelaglgkvplkrafdlin
ylgnenhtapitealfqtdliynlleklgymdlasrlvtrvfkllqnqiqqqtwtdegtp
smrelrsallefacthnlgncsttamklfddwmasngtqslptdvmttvfkvgaktdkgw
sfllgkyisigseaeknkilealassedvrklywlmksslngdnfrtqklsfiirtvgrh
fpghllawdfvkenwnklvqkfplgsytiqnivagstylfstkthlsevqaffenqseat
frlrcvqealeviqlniqwmeknlksltwwlrtetsqvapa

    Sequence, based on observed residues (ATOM records): (download) 
    >5mj6A (A:)
ngklfpwaqirlptavvplryelslhpnltsmtfrgsvtisvqalqvtwniilhstghni
srvtfmsavssqekqaeileyayhgqiaivapeallaghnytlkieysanisssyygfyg
fsytdesnekkyfaatqfeplaarsafpcfdepafkatfiikiirdeqytalsnmpkkss
vvlddglvqdefsesvkmstylvafivgemknlsqdvngtlvsiyavpekigqvhyalet
tvklleffqnyfeiqyplkkldlvaipdfeagamenwglltfreetllydsntssmadrk
lvtkiiahelahqwfgnlvtmkwwndlwlnegfatfmeyfslekifkelssyedfldarf
ktmkkdslnsshpisssvqsseqieemfdslsyfkgsslllmlktylsedvfqhavvlyl
hnhsyasiqsddlwdsfnevtnqtldvkrmmktwtlqkgfplvtvqkkgkelfiqqerff
lnmsylwhiplsyvtegrnyskyqsvslldkksgvinlteevlwvkvninmngyyivhya
dddwealihqlkinpyvlsdkdranlinnifelaglgkvplkrafdlinylgnenhtapi
tealfqtdliynlleklgymdlasrlvtrvfkllqnqiqqqtwtdegtpsmrelrsalle
facthnlgncsttamklfddwmasngtqslptdvmttvfkvgaktdkgwsfllgkyisig
seaeknkilealassedvrklywlmksslngdnfrtqklsfiirtvgrhfpghllawdfv
kenwnklvqkfplgsytiqnivagstylfstkthlsevqaffenqseatfrlrcvqeale
viqlniqwmeknlksltwwlrtetsqvapa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5mj6B (B:)
atngklfpwaqirlptavvplryelslhpnltsmtfrgsvtisvqalqvtwniilhstgh
nisrvtfmsavssqekqaeileyayhgqiaivapeallaghnytlkieysanisssyygf
ygfsytdesnekkyfaatqfeplaarsafpcfdepafkatfiikiirdeqytalsnmpkk
ssvvlddglvqdefsesvkmstylvafivgemknlsqdvngtlvsiyavpekigqvhyal
ettvklleffqnyfeiqyplkkldlvaipdfeagamenwglltfreetllydsntssmad
rklvtkiiahelahqwfgnlvtmkwwndlwlnegfatfmeyfslekifkelssyedflda
rfktmkkdslnsshpisssvqsseqieemfdslsyfkgsslllmlktylsedvfqhavvl
ylhnhsyasiqsddlwdsfnevtnqtldvkrmmktwtlqkgfplvtvqkkgkelfiqqer
fflnmkpeiqpsdtsylwhiplsyvtegrnyskyqsvslldkksgvinlteevlwvkvni
nmngyyivhyadddwealihqlkinpyvlsdkdranlinnifelaglgkvplkrafdlin
ylgnenhtapitealfqtdliynlleklgymdlasrlvtrvfkllqnqiqqqtwtdegtp
smrelrsallefacthnlgncsttamklfddwmasngtqslptdvmttvfkvgaktdkgw
sfllgkyisigseaeknkilealassedvrklywlmksslngdnfrtqklsfiirtvgrh
fpghllawdfvkenwnklvqkfplgsytiqnivagstylfstkthlsevqaffenqseat
frlrcvqealeviqlniqwmeknlksltwwlrtetsqvapa

    Sequence, based on observed residues (ATOM records): (download) 
    >5mj6B (B:)
lfpwaqirlptavvplryelslhpnltsmtfrgsvtisvqalqvtwniilhstghnisrv
tfmsavssqekqaeileyayhgqiaivapeallaghnytlkieysanisssyygfygfsy
tdesnekkyfaatqfeplaarsafpcfdepafkatfiikiirdeqytalsnmpkkssvvl
ddglvqdefsesvkmstylvafivgemknlsqdvngtlvsiyavpekigqvhyalettvk
lleffqnyfeiqyplkkldlvaipdfeagamenwglltfreetllydsntssmadrklvt
kiiahelahqwfgnlvtmkwwndlwlnegfatfmeyfslekifkelssyedfldarfktm
kkdslnsshpisssvqsseqieemfdslsyfkgsslllmlktylsedvfqhavvlylhnh
syasiqsddlwdsfnevtnqtldvkrmmktwtlqkgfplvtvqkkgkelfiqqerfflns
ylwhiplsyvtegrnyskyqsvslldkksgvinlteevlwvkvninmngyyivhyadddw
ealihqlkinpyvlsdkdranlinnifelaglgkvplkrafdlinylgnenhtapiteal
fqtdliynlleklgymdlasrlvtrvfkllqnqiqqqtwtdegtpsmrelrsallefact
hnlgncsttamklfddwmasngtqslptdvmttvfkvgaktdkgwsfllgkyisigseae
knkilealassedvrklywlmksslngdnfrtqklsfiirtvgrhfpghllawdfvkenw
nklvqkfplgsytiqnivagstylfstkthlsevqaffenqseatfrlrcvqealeviql
niqwmeknlksltwwlrtetsqvapa