PDB entry 5mev

View 5mev on RCSB PDB site
Description: mcl1 fab complex in complex with compound 21
Class: immune system
Keywords: MCL1 FAB macrocycle, MCL1-FAB_55_C6HIS, immune system
Deposited on 2016-11-16, released 2017-01-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 2.94 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5meva_
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5MEV (0-End)
    Domains in SCOPe 2.08: d5mevh_
  • Chain 'L':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5MEV
    Domains in SCOPe 2.08: d5mevl1, d5mevl2
  • Heterogens: 7LW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5mevA (A:)
gplgseddlyrqsleiisrylreqatgskdskplgeagaagrraletlrrvgdgvqrnhe
tafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqes
cieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >5mevA (A:)
ddlyrqsleiisrylreqatgskdskplgeagaagrraletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhve

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5mevH (H:)
qvtlkesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisssssyiyy
adsvkgrftisrdnaknslylqmnslraedtavyycarqvgatwafdiwgqgtlvtvsaa
kttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdl
ytlsssvtvpssprpsetvtcnvahpasstkvdkkivprdcaaaenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >5mevH (H:)
qvtlkesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisssssyiyy
adsvkgrftisrdnaknslylqmnslraedtavyycarqvgatwafdiwgqgtlvtvsaa
kttppsvyplapgmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssv
tvpssetvtcnvahpasstkvdkkivp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5mevL (L:)
qsvltqppsasgtpgqrvtiscsgsssnigsntvnwyqqlpgtapklliysnnqrpsgvp
drfsgsksgtsaslaisglqsedeadyycaawddslnawvfgggtkltvlgqpksspsvt
lfppsseeletnkatlvctitdfypgvvtvdwkvdgtpvtqgmettqpskqsnnkymass
yltltarawerhssyscqvtheghtvekslsradcaaaenlyfqgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5mevL (L:)
svltqppsasgtpgqrvtiscsgsssnigsntvnwyqqlpgtapklliysnnqrpsgvpd
rfsgsksgtsaslaisglqsedeadyycaawddslnawvfgggtkltvlgqpksspsvtl
fppsseeletnkatlvctitdfypgvvtvdwkvdgtpvtqgmettqpskqsnnkymassy
ltltarawerhssyscqvtheghtvekslsrad