PDB entry 5m7e

View 5m7e on RCSB PDB site
Description: Tubulin-BKM120 complex
Class: cell cycle
Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
Deposited on 2016-10-27, released 2017-02-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-02-22, with a file datestamp of 2017-02-17.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha-1B chain
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5m7ea1, d5m7ea2
  • Chain 'B':
    Compound: Tubulin beta-2B chain
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5m7eb1, d5m7eb2
  • Chain 'C':
    Compound: Tubulin alpha-1B chain
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5m7ec1, d5m7ec2
  • Chain 'D':
    Compound: Tubulin beta-2B chain
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5m7ed1, d5m7ed2
  • Chain 'E':
    Compound: Stathmin-4
    Species: Rattus norvegicus [TaxId:10116]
    Gene: STMN4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5m7ee_
  • Chain 'F':
    Compound: Uncharacterized protein
    Species: Gallus gallus [TaxId:9031]
    Gene: TTL
    Database cross-references and differences (RAF-indexed):
    • Uniprot E1BQ43 (0-377)
      • expression tag (378)
    Domains in SCOPe 2.06: d5m7ef1, d5m7ef2, d5m7ef3
  • Heterogens: GTP, MG, CA, GOL, GDP, MES, SD5, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5m7eA (A:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsvegegeeegeey
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m7eA (A:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5m7eB (B:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
    epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
    lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatadeqgefeeeegedea
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m7eB (B:)
    reivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyvp
    railvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvvr
    kesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvve
    pynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttclr
    fpgqlnadlrklavnmvpfprlhffmpgfapltsqyraltvpeltqqmfdsknmmaacdp
    rhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkmsa
    tfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqqy
    qda
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5m7eC (C:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsvegegeeegeey
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m7eC (C:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5m7eD (D:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
    epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
    lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatadeqgefeeeegedea
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m7eD (D:)
    reivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyvp
    railvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvvr
    kesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvve
    pynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttclr
    fpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqaltvpeltqqmfdsknmmaacd
    prhgryltvaaifrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprglkms
    atfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvseyqq
    yqdatad
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5m7eE (E:)
    madmevielnkctsgqsfevilkppsfdgvpefnaslprrrdpsleeiqkkleaaeerrk
    yqeaellkhlaekrehereviqkaieennnfikmakeklaqkmesnkenreahlaamler
    lqekdkhaeevrknkelkeeasr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m7eE (E:)
    mevielnkctsgqsfevilkppsdpsleeiqkkleaaeerrkyqeaellkhlaekreher
    eviqkaieennnfikmakeklaqkmesnkenreahlaamlerlqekdkhaeevrknkelk
    eea
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5m7eF (F:)
    mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
    lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptnlktpvapaqngirhli
    nntrtderevflaaynrrregregnvwiakssagakgegilisseaselldfideqgqvh
    viqkylekplllepghrkfdirswvlvdhlyniylyregvlrtssepynsanfqdktchl
    tnhciqkeysknygryeegnemffeefnqylmdalnttlensillqikhiirsclmciep
    aistkhlhyqsfqlfgfdfmvdeelkvwlievngapacaqklyaelcqgivdvaissvfp
    ladtgqktsqptsifiklhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m7eF (F:)
    mytfvvrdenssvyaevsrlllatgqwkrlrkdnprfnlmlgernrlpfgrlghepglvq
    lvnyyrgadklcrkaslvkliktspelsesctwfpesyviyptderevflaayngnvwia
    kssagilisseaselldfvhviqkylekplllepghrkfdirswvlvdhlyniylyregv
    lrtssepynsadktchltnhciqkygryeegnemffeefnqylmdalnttlensillqik
    hiirsclmciepaistkhlhyqsfqlfgfdfmvdeelkvwlievngapacaqklyaelcq
    givdvaissvfplatsifiklh