PDB entry 5m4e
View 5m4e on RCSB PDB site
Description: Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
Class: transferase
Keywords: Off-Rate Screening, PDHK, HSP90, SPR, kinase inhibitors, fragment screening, cancer, PDK1, PDK2, PDK3, PDK4, transferase
Deposited on
2016-10-18, released
2017-02-22
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-04-05, with a file datestamp of
2017-03-31.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Heat shock protein HSP 90-alpha
Species: Homo sapiens [TaxId:9606]
Gene: HSP90AA1, HSP90A, HSPC1, HSPCA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5m4ea_ - Heterogens: 7F9, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5m4eA (A:)
mghhhhhhhhhhssghiddadkhmdqpmeeeevetfafqaeiaqlmsliintfysnkeif
lrelisnssdaldkiryesltdpskldsgkelhinlipnkqdrtltivdtgigmtkadli
nnlgtiaksgtkafmealqagadismigqfgvgfysaylvaekvtvitkhnddeqyawes
saggsftvrtdtgepmgrgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvek
erdkevsddeae
Sequence, based on observed residues (ATOM records): (download)
>5m4eA (A:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfve