PDB entry 5m2j

View 5m2j on RCSB PDB site
Description: Complex between human TNF alpha and Llama VHH2
Class: cytokine
Keywords: human TNF alpha Llama VHH2, cytokine
Deposited on 2016-10-13, released 2017-08-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5m2ja_
  • Chain 'D':
    Compound: Anti-(ED-B) scFV
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5M2J (0-114)
    Domains in SCOPe 2.06: d5m2jd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5m2jA (A:)
    vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
    qvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiyl
    ggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial
    

    Sequence, based on observed residues (ATOM records): (download)
    >5m2jA (A:)
    sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
    cpsthvllthtisriavsyqtkvnllsaikspcqpwyepiylggvfqlekgdrlsaeinr
    pdyldfaesgqvyfgiial
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5m2jD (D:)
    qvqlvesggglvqpggslrlscaasgftfsnywmywvrqapgkglewvseintnglitky
    pdsvkgrftisrdnakntlylqmnslkpedtalyycarspsgfnrgqgtqvtvss