PDB entry 5lx5

View 5lx5 on RCSB PDB site
Description: crystal structure of visfatin in complex with sar154782-rp.
Class: transferase
Keywords: transferase, nampt, inhibitor, drug design, cancer
Deposited on 2016-09-20, released 2017-10-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5lx5a1, d5lx5a2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5lx5b1, d5lx5b2
  • Heterogens: 7A0, DPO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5lx5A (A:)
gamnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetv
fyglqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieika
vpegfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakylle
tsgnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvp
gysvpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhl
ivsrstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdi
ntlqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpv
adpnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirk
naqlnieleaahh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lx5A (A:)
fnillatdsykvthykqyppntskvysyfecreyeetvfyglqyilnkylkgkvvtkeki
qeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftventdpe
cywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyrgvss
qetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdhekd
afehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnpldt
vlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsieniaf
gsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpagnf
vtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqln

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5lx5B (B:)
gamnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetv
fyglqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieika
vpegfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakylle
tsgnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvp
gysvpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhl
ivsrstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdi
ntlqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpv
adpnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirk
naqlnieleaahh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lx5B (B:)
fnillatdsykvthykqyppntskvysyfecreyeetvfyglqyilnkylkgkvvtkeki
qeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftventdpe
cywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyrgvss
qetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdhekd
afehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnpldt
vlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsieniaf
gsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpagnf
vtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqln