PDB entry 5lls

View 5lls on RCSB PDB site
Description: Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Class: hydrolase
Keywords: peptidase, inhibitor, complex, hydrolase
Deposited on 2016-07-28, released 2016-09-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-09-14, with a file datestamp of 2016-09-09.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5llsa1, d5llsa2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5llsb1, d5llsb2
  • Chain 'C':
    Compound: dipeptidyl peptidase 4
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5llsc1, d5llsc2
  • Chain 'D':
    Compound: dipeptidyl peptidase 4
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5llsd1, d5llsd2
  • Heterogens: NAG, 6Z8, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5llsA (A:)
mktpwkvllgllgiaalvtvitvpvvllnkgtddaaadsrrtytltdylkstfrvkfytl
qwisdheylykqennillfnaeygnssiflenstfdelgystndysvspdrqfilfeyny
vkqwrhsytasydiydlnkrqliteeripnntqwitwspvghklayvwnndiyvknepnl
ssqritwtgkenviyngvtdwvyeeevfsaysalwwspngtflayaqfndtevplieysf
ysdeslqypktvripypkagaenptvkffvvdtrtlspnasvtsyqivppasvligdhyl
cgvtwvteerislqwirraqnysiidicdydestgrwissvarqhieisttgwvgrfrpa
ephftsdgnsfykiisneegykhichfqtdksnctfitkgawevigiealtsdylyyisn
ehkgmpggrnlyriqlndytkvtclscelnpercqyysasfsnkakyyqlrcfgpglply
tlhssssdkelrvlednsaldkmlqdvqmpskkldvinlhgtkfwyqmilpphfdkskky
pllievyagpcsqkvdtvfrlswatylasteniivasfdgrgsgyqgdkimhainrrlgt
fevedqieatrqfskmgfvddkriaiwgwsyggyvtsmvlgagsgvfkcgiavapvskwe
yydsvyterymglptpednldyyrnstvmsraenfkqveyllihgtaddnvhfqqsaqls
kalvdagvdfqtmwytdedhgiasnmahqhiythmshflkqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5llsA (A:)
rrtytltdylkstfrvkfytlqwisdheylykqennillfnaeygnssiflenstfdelg
ystndysvspdrqfilfeynyvkqwrhsytasydiydlnkrqliteeripnntqwitwsp
vghklayvwnndiyvknepnlssqritwtgkenviyngvtdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvripypkagaenptvkffvvdtrtlspn
asvtsyqivppasvligdhylcgvtwvteerislqwirraqnysiidicdydestgrwis
svarqhieisttgwvgrfrpaephftsdgnsfykiisneegykhichfqtdksnctfitk
gawevigiealtsdylyyisnehkgmpggrnlyriqlndytkvtclscelnpercqyysa
sfsnkakyyqlrcfgpglplytlhssssdkelrvlednsaldkmlqdvqmpskkldvinl
hgtkfwyqmilpphfdkskkypllievyagpcsqkvdtvfrlswatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieatrqfskmgfvddkriaiwgwsyggyvtsmv
lgagsgvfkcgiavapvskweyydsvyterymglptpednldyyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqlskalvdagvdfqtmwytdedhgiasnmahqhiythmshfl
kqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5llsB (B:)
mktpwkvllgllgiaalvtvitvpvvllnkgtddaaadsrrtytltdylkstfrvkfytl
qwisdheylykqennillfnaeygnssiflenstfdelgystndysvspdrqfilfeyny
vkqwrhsytasydiydlnkrqliteeripnntqwitwspvghklayvwnndiyvknepnl
ssqritwtgkenviyngvtdwvyeeevfsaysalwwspngtflayaqfndtevplieysf
ysdeslqypktvripypkagaenptvkffvvdtrtlspnasvtsyqivppasvligdhyl
cgvtwvteerislqwirraqnysiidicdydestgrwissvarqhieisttgwvgrfrpa
ephftsdgnsfykiisneegykhichfqtdksnctfitkgawevigiealtsdylyyisn
ehkgmpggrnlyriqlndytkvtclscelnpercqyysasfsnkakyyqlrcfgpglply
tlhssssdkelrvlednsaldkmlqdvqmpskkldvinlhgtkfwyqmilpphfdkskky
pllievyagpcsqkvdtvfrlswatylasteniivasfdgrgsgyqgdkimhainrrlgt
fevedqieatrqfskmgfvddkriaiwgwsyggyvtsmvlgagsgvfkcgiavapvskwe
yydsvyterymglptpednldyyrnstvmsraenfkqveyllihgtaddnvhfqqsaqls
kalvdagvdfqtmwytdedhgiasnmahqhiythmshflkqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5llsB (B:)
rrtytltdylkstfrvkfytlqwisdheylykqennillfnaeygnssiflenstfdelg
ystndysvspdrqfilfeynyvkqwrhsytasydiydlnkrqliteeripnntqwitwsp
vghklayvwnndiyvknepnlssqritwtgkenviyngvtdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvripypkagaenptvkffvvdtrtlspn
asvtsyqivppasvligdhylcgvtwvteerislqwirraqnysiidicdydestgrwis
svarqhieisttgwvgrfrpaephftsdgnsfykiisneegykhichfqtdksnctfitk
gawevigiealtsdylyyisnehkgmpggrnlyriqlndytkvtclscelnpercqyysa
sfsnkakyyqlrcfgpglplytlhssssdkelrvlednsaldkmlqdvqmpskkldvinl
hgtkfwyqmilpphfdkskkypllievyagpcsqkvdtvfrlswatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieatrqfskmgfvddkriaiwgwsyggyvtsmv
lgagsgvfkcgiavapvskweyydsvyterymglptpednldyyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqlskalvdagvdfqtmwytdedhgiasnmahqhiythmshfl
kqcfslp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5llsC (C:)
mktpwkvllgllgiaalvtvitvpvvllnkgtddaaadsrrtytltdylkstfrvkfytl
qwisdheylykqennillfnaeygnssiflenstfdelgystndysvspdrqfilfeyny
vkqwrhsytasydiydlnkrqliteeripnntqwitwspvghklayvwnndiyvknepnl
ssqritwtgkenviyngvtdwvyeeevfsaysalwwspngtflayaqfndtevplieysf
ysdeslqypktvripypkagaenptvkffvvdtrtlspnasvtsyqivppasvligdhyl
cgvtwvteerislqwirraqnysiidicdydestgrwissvarqhieisttgwvgrfrpa
ephftsdgnsfykiisneegykhichfqtdksnctfitkgawevigiealtsdylyyisn
ehkgmpggrnlyriqlndytkvtclscelnpercqyysasfsnkakyyqlrcfgpglply
tlhssssdkelrvlednsaldkmlqdvqmpskkldvinlhgtkfwyqmilpphfdkskky
pllievyagpcsqkvdtvfrlswatylasteniivasfdgrgsgyqgdkimhainrrlgt
fevedqieatrqfskmgfvddkriaiwgwsyggyvtsmvlgagsgvfkcgiavapvskwe
yydsvyterymglptpednldyyrnstvmsraenfkqveyllihgtaddnvhfqqsaqls
kalvdagvdfqtmwytdedhgiasnmahqhiythmshflkqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5llsC (C:)
rrtytltdylkstfrvkfytlqwisdheylykqennillfnaeygnssiflenstfdelg
ystndysvspdrqfilfeynyvkqwrhsytasydiydlnkrqliteeripnntqwitwsp
vghklayvwnndiyvknepnlssqritwtgkenviyngvtdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvripypkagaenptvkffvvdtrtlspn
asvtsyqivppasvligdhylcgvtwvteerislqwirraqnysiidicdydestgrwis
svarqhieisttgwvgrfrpaephftsdgnsfykiisneegykhichfqtdksnctfitk
gawevigiealtsdylyyisnehkgmpggrnlyriqlndytkvtclscelnpercqyysa
sfsnkakyyqlrcfgpglplytlhssssdkelrvlednsaldkmlqdvqmpskkldvinl
hgtkfwyqmilpphfdkskkypllievyagpcsqkvdtvfrlswatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieatrqfskmgfvddkriaiwgwsyggyvtsmv
lgagsgvfkcgiavapvskweyydsvyterymglptpednldyyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqlskalvdagvdfqtmwytdedhgiasnmahqhiythmshfl
kqcfslp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5llsD (D:)
mktpwkvllgllgiaalvtvitvpvvllnkgtddaaadsrrtytltdylkstfrvkfytl
qwisdheylykqennillfnaeygnssiflenstfdelgystndysvspdrqfilfeyny
vkqwrhsytasydiydlnkrqliteeripnntqwitwspvghklayvwnndiyvknepnl
ssqritwtgkenviyngvtdwvyeeevfsaysalwwspngtflayaqfndtevplieysf
ysdeslqypktvripypkagaenptvkffvvdtrtlspnasvtsyqivppasvligdhyl
cgvtwvteerislqwirraqnysiidicdydestgrwissvarqhieisttgwvgrfrpa
ephftsdgnsfykiisneegykhichfqtdksnctfitkgawevigiealtsdylyyisn
ehkgmpggrnlyriqlndytkvtclscelnpercqyysasfsnkakyyqlrcfgpglply
tlhssssdkelrvlednsaldkmlqdvqmpskkldvinlhgtkfwyqmilpphfdkskky
pllievyagpcsqkvdtvfrlswatylasteniivasfdgrgsgyqgdkimhainrrlgt
fevedqieatrqfskmgfvddkriaiwgwsyggyvtsmvlgagsgvfkcgiavapvskwe
yydsvyterymglptpednldyyrnstvmsraenfkqveyllihgtaddnvhfqqsaqls
kalvdagvdfqtmwytdedhgiasnmahqhiythmshflkqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5llsD (D:)
rrtytltdylkstfrvkfytlqwisdheylykqennillfnaeygnssiflenstfdelg
ystndysvspdrqfilfeynyvkqwrhsytasydiydlnkrqliteeripnntqwitwsp
vghklayvwnndiyvknepnlssqritwtgkenviyngvtdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvripypkagaenptvkffvvdtrtlspn
asvtsyqivppasvligdhylcgvtwvteerislqwirraqnysiidicdydestgrwis
svarqhieisttgwvgrfrpaephftsdgnsfykiisneegykhichfqtdksnctfitk
gawevigiealtsdylyyisnehkgmpggrnlyriqlndytkvtclscelnpercqyysa
sfsnkakyyqlrcfgpglplytlhssssdkelrvlednsaldkmlqdvqmpskkldvinl
hgtkfwyqmilpphfdkskkypllievyagpcsqkvdtvfrlswatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieatrqfskmgfvddkriaiwgwsyggyvtsmv
lgagsgvfkcgiavapvskweyydsvyterymglptpednldyyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqlskalvdagvdfqtmwytdedhgiasnmahqhiythmshfl
kqcfslp