PDB entry 5lj2

View 5lj2 on RCSB PDB site
Description: N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)piperidin-4-yl)amino)-3-methyl-1,7-naphthyridin-2(1H)-one
Class: transcription
Keywords: INHIBITOR, HISTONE, EPIGENETIC READER, BROMODOMAIN, BRD4, BROMODOMAIN CONTAINING PROTEIN 4, ANTAGONIST, transcription
Deposited on 2016-07-17, released 2016-08-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-09-14, with a file datestamp of 2016-09-09.
Experiment type: XRAY
Resolution: 1.19 Å
R-factor: N/A
AEROSPACI score: 0.66 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (0-126)
    • conflict (1)
  Domains in SCOPe 2.08: d5lj2a_
• Heterogens: EDO, 6XW, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5lj2A (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee