PDB entry 5lhn

View 5lhn on RCSB PDB site
Description: The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Class: Hydrolase/Antibody
Keywords: Trypsin-like serine proteases, Nanobody, Inhibitor, Hydrolase-Antibody complex
Deposited on 2016-07-12, released 2017-06-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-06-28, with a file datestamp of 2017-06-23.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: urokinase-type plasminogen activator
    Species: Mus musculus [TaxId:10090]
    Gene: PLAU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06869 (0-246)
      • engineered mutation (121)
    Domains in SCOPe 2.08: d5lhna_
  • Chain 'B':
    Compound: Camelid-Derived Antibody Fragment Nb7
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5LHN (0-End)
    Domains in SCOPe 2.08: d5lhnb1, d5lhnb2
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5lhnA (A:)
ivggeftevenqpwfaaiyqknkggsppsfkcggslispcwvasaahcfiqlpkkenyvv
ylgqskessynpgemkfeveqlilheyyredslayhndiallkirtstgqcaqpsrsiqt
ialpprftdapfgsdceitgfgkesesdylypknlkmsvvklvsheqcmqphyygseiny
kmlcaadpewktdsckgdsggplicniegrptlsgivswgrgcaeknkpgvytrvshfld
wiqshig

    Sequence, based on observed residues (ATOM records): (download) 
    >5lhnA (A:)
ivggeftevenqpwfaaiyqknkggsppsfkcggslispcwvasaahcfiqlpkkenyvv
ylgqskessynpgemkfeveqlilheyyredslayhndiallkirtstgqcaqpsrsiqt
ialpprftdapfgsdceitgfgkknlkmsvvklvsheqcmqphyygseinykmlcaadpe
wktdsckgdsggplicniegrptlsgivswgrgcaeknkpgvytrvshfldwiqshig

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5lhnB (B:)
qvqlqesggglvqpggslrlscaasgftlgyyaigwfrrapgkeregvscisssggstny
adsvkgrftisrdnakntvdlqmnslkpedtaiyycaaewvppgygatvqalcnnagygm
eywgkgtqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lhnB (B:)
qvqlqesggglvqpggslrlscaasgftlgyyaigwfrrapgkeregvscisssggstny
adsvkgrftisrdnakntvdlqmnslkpedtaiyycaaewvppgygatvqalcnnagygm
eywgkgtqvtvssaa