PDB entry 5lgu

View 5lgu on RCSB PDB site
Description: thieno[3,2-b]pyrrole-5-carboxamides as novel reversible inhibitors of histone lysine demethylase kdm1a/lsd1: compound 34
Deposited on 2016-07-08, released 2017-02-22
The last revision was dated 2017-03-22, with a file datestamp of 2017-03-17.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1A
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM1A, AOF2, KDM1, KIAA0601, LSD1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RCOR1, KIAA0071, RCOR
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FAD, 6W1

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.07, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >5lguA (A:)
    mdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgvegaafqsr
    lphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfeatlqqleapy
    nsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsglaaarqlqsfgm
    dvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnmelakikqkcpl
    yeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqalevviqlqekh
    vkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkpprditaeflvks
    khrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwhfanlefanat
    plstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrqvrytasgcev
    iavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavqrmgfgnlnkv
    vlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaagimenisddv
    ivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgndydlmaqpitp
    gpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflgamytlprqatp
    gvpaqqspsm
    

    Sequence, based on observed residues (ATOM records):
    >5lguA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamytl
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >5lguB (B:)
    rakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekld
    ggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvny
    rrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryasas
    

    Sequence, based on observed residues (ATOM records):
    >5lguB (B:)
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweae