PDB entry 5lby

View 5lby on RCSB PDB site
Description: Structure of the human quinone reductase 2 (NQO2) in complex with crenolanib
Class: oxidoreductase
Keywords: quinone reductase 2, kinase inhibitor, crenolanib, Ribosyldihydronicotinamide dehydrogenase, oxidoreductase
Deposited on 2016-06-17, released 2017-11-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-11-29, with a file datestamp of 2017-11-24.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lbya_
  • Chain 'B':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lbyb_
  • Heterogens: ZN, FAD, 6T2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5lbyA (A:)
magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtl
snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lbyA (A:)
gkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtlsn
pevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvlc
qgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcgf
kvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5lbyB (B:)
magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtl
snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lbyB (B:)
gkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtlsn
pevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvlc
qgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcgf
kvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfg