PDB entry 5lbw

View 5lbw on RCSB PDB site
Description: Structure of the human quinone reductase 2 (NQO2) in complex with volitinib
Class: oxidoreductase
Keywords: quinone reductase 2, kinase inhibitor, volitinib, Ribosyldihydronicotinamide dehydrogenase, oxidoreductase
Deposited on 2016-06-17, released 2017-11-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-13, with a file datestamp of 2017-12-08.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5lbwa_
  • Chain 'B':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5lbwb_
  • Heterogens: ZN, FAD, V0L, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5lbwA (A:)
    magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtl
    snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
    lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
    gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgqhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5lbwA (A:)
    kkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtlsnp
    evfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvlcq
    gfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcgfk
    vlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5lbwB (B:)
    magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtl
    snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
    lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
    gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgqhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5lbwB (B:)
    gkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnlepratdkditgtlsn
    pevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvlc
    qgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcgf
    kvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfg