PDB entry 5lb6

View 5lb6 on RCSB PDB site
Description: HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Class: oxidoreductase
Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, DNA-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
Deposited on 2016-06-15, released 2016-08-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-09-07, with a file datestamp of 2016-09-02.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Egl nine homolog 1
  Species: Homo sapiens [TaxId:9606]
  Gene: EGLN1, C1orf12, PNAS-118, PNAS-137
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9GZT9
    • engineered mutation (196)
  Domains in SCOPe 2.08: d5lb6a_
• Heterogens: MN, UN9, SO4, GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >5lb6A (A:)
  gshmaspngqtkplpalklaleyivpcmnkhgicvvddflgketgqqigdevralhdtgk
  ftdgqlvsqksdsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsyking
  rtkamvacypgngtgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfa
  diepkfdrllffwsdrhnphevqpayatryaitvwyfdaderarakvkyltgekgvrvel
  nkpsdsvgkdvf
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5lb6A (A:)
  lpalklaleyivpcmnkhgicvvddflgketgqqigdevralhdtgkftdgqlvsqksds
  skdirgdkitwiegkepgcetigllmssmddlirhcngklgsykingrtkamvacypgng
  tgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfadiepkfdrllffw
  sdrhnphevqpayatryaitvwyfdaderarakvkylkgvr