PDB entry 5lax

View 5lax on RCSB PDB site
Description: Crystal structure of HLA_DRB1*04:01 in complex with alpha-enolase peptide 26-40
Class: immune system
Keywords: HLA, autoimmune desease, rheumathoid arthritis, MHC class II, immune system
Deposited on 2016-06-15, released 2016-12-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-12-07, with a file datestamp of 2016-12-02.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01903 (Start-180)
      • expression tag (181)
    Domains in SCOPe 2.08: d5laxa1, d5laxa2, d5laxa3
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13760 (0-189)
      • expression tag (190-192)
    Domains in SCOPe 2.08: d5laxb1, d5laxb2, d5laxb3
  • Chain 'C':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5laxc1, d5laxc2
  • Chain 'D':
    Compound: HLA class II histocompatibility antigen, DRB1-4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13760 (Start-189)
      • expression tag (190)
    Domains in SCOPe 2.08: d5laxd1, d5laxd2, d5laxd3
  • Chain 'E':
    Compound: alpha-enolase peptideTSKGLFRAAVPSGAS
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5LAX (Start-14)
  • Chain 'F':
    Compound: alpha-enolase peptideTSKGLFRAAVPSGAS
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5LAX (Start-14)
  • Heterogens: MLA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5laxA (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
dssadlvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >5laxA (A:)
keehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgala
niavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtw
lrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
s

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5laxB (B:)
gdtrprfleqvkhechffngtervrfldryfyhqeeyvrfdsdvgeyravtelgrpdaey
wnsqkdlleqkraavdtycrhnygvgesftvqrrvypevtvypaktqplqhhnllvcsvn
gfypgsievrwfrngqeektgvvstgliqngdwtfqtlvmletvprsgevytcqvehpsl
tspltvewrassadlvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >5laxB (B:)
gdtrprfleqvkhechffngtervrfldryfyhqeeyvrfdsdvgeyravtelgrpdaey
wnsqkdlleqkraavdtycrhnygvgesftvqrrvypevtvypaktqplqhhnllvcsvn
gfypgsievrwfrngqeektgvvstgliqngdwtfqtlvmletvprsgevytcqvehpsl
tspltvewrassa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5laxC (C:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
dssadlvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >5laxC (C:)
keehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgala
niavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtw
lrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5laxD (D:)
gdtrprfleqvkhechffngtervrfldryfyhqeeyvrfdsdvgeyravtelgrpdaey
wnsqkdlleqkraavdtycrhnygvgesftvqrrvypevtvypaktqplqhhnllvcsvn
gfypgsievrwfrngqeektgvvstgliqngdwtfqtlvmletvprsgevytcqvehpsl
tspltvewrassadlvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >5laxD (D:)
rprfleqvkhechffngtervrfldryfyhqeeyvrfdsdvgeyravtelgrpdaeywns
qkdlleqkraavdtycrhnygvgesftvqrrvypevtvypaktqplqhhnllvcsvngfy
pgsievrwfrngqeektgvvstgliqngdwtfqtlvmletvprsgevytcqvehpsltsp
ltvewras

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.