PDB entry 5l8h

View 5l8h on RCSB PDB site
Description: Structure of USP46-UbVME
Class: hydrolase
Keywords: Ubiquitin Specific Protease, Deubiquitinating enzyme, hydrolase
Deposited on 2016-06-07, released 2016-09-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-07, with a file datestamp of 2016-12-02.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin carboxyl-terminal hydrolase 46
    Species: Homo sapiens [TaxId:9606]
    Gene: USP46
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62068 (Start-358)
      • conflict (38)
      • conflict (257)
    Domains in SCOPe 2.07: d5l8ha_
  • Chain 'B':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (0-75)
      • engineered mutation (75)
    Domains in SCOPe 2.07: d5l8hb_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5l8hA (A:)
    sicnmgtnasalekdigpeqfpinehyfglvnfgntcyvnsvlqalyfcrpfrenvlayk
    aqqkkkenlltcladlfhsiatqkkkvgvippkkfisrlrkendlfdnymqqdaheflny
    llntiadilqeekkqekqngklkngnmnepaennkpeltwvheifqgtltnetrclncet
    vsskdedfldlsvdveqntsithclrdfsntetlcseqkyycetccskqeaqkrmrvkkl
    pmilalhlkrfkymeqlrrytklsyrvvfplelrlfntssdavnldrmydlvavvvhcgs
    gpnrghyitivkshgfwllfdddivekidaqaieefygltsdisknsesgyilfyqsre
    

    Sequence, based on observed residues (ATOM records): (download)
    >5l8hA (A:)
    nehyfglvnfgntcyvnsvlqalyfcrpfrenvlaykaqqkkkenlltcladlfhsiatq
    kkkvgvippkkfisrlrkendlfdnymqqdaheflnyllntiadilqeekkqeltwvhei
    fqgtltnetrclncetvsskdedfldlsvdveqntsithclrdfsntetlcseqkyycet
    ccskqeaqkrmrvkklpmilalhlkrfkymeqlrrytklsyrvvfplelrlfntsnldrm
    ydlvavvvhcgsgpnrghyitivkshgfwllfdddivekidaqaieefygltsdisknse
    sgyilfyqsre
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5l8hB (B:)
    mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
    iqkestlhlvlrlrgx