PDB entry 5l3a

View 5l3a on RCSB PDB site
Description: Fragment-based discovery of 6-arylindazole JAK inhibitors
Class: transferase
Keywords: Double F mutant, transferase
Deposited on 2016-04-06, released 2016-04-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (169-170)
    Domains in SCOPe 2.08: d5l3aa_
  • Heterogens: 6DP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5l3aA (A:)
gsdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfer
eieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqyt
sqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeffkvkepgesp
ifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfh
liellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >5l3aA (A:)
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeffkvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm