PDB entry 5kyk

View 5kyk on RCSB PDB site
Description: Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: KRAS, Cancer, covalent inhibitor, HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2016-07-21, released 2017-04-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-04-12, with a file datestamp of 2017-04-07.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-End)
      • expression tag (0)
      • engineered mutation (12)
    Domains in SCOPe 2.06: d5kyka1, d5kyka2
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-168)
      • expression tag (0)
      • engineered mutation (12)
    Domains in SCOPe 2.06: d5kykb1, d5kykb2
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-168)
      • expression tag (0)
      • engineered mutation (12)
    Domains in SCOPe 2.06: d5kykc1, d5kykc2
  • Heterogens: 6ZD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kykA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >5kykA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeyddsyrkqvvidgetclldildtagqer
dqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtk
qaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kykB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >5kykB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeyddsyrkqvvidgetclldildtagqer
dqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtk
qaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5kykC (C:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >5kykC (C:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydpdsyrkqvvidgetclldildtagqe
samrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrt
vdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke