PDB entry 5ktu

View 5ktu on RCSB PDB site
Description: Crystal structure of the bromodomain of human CREBBP bound to pyrazolopiperidine scaffold
Class: transferase
Keywords: bromodomain, inhibitor, epigenetics, TRANSFERASE
Deposited on 2016-07-12, released 2016-11-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-12-21, with a file datestamp of 2016-12-16.
Experiment type: XRAY
Resolution: 1.38 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: creb-binding protein
    Species: Homo sapiens [TaxId:9606]
    Gene: CREBBP, CBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ktua_
  • Chain 'B':
    Compound: creb-binding protein
    Species: Homo sapiens [TaxId:9606]
    Gene: CREBBP, CBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ktub_
  • Heterogens: 6XB, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ktuA (A:)
gskkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstik
rkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ktuA (A:)
elrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkldtgqyq
epwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ktuB (B:)
gskkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstik
rkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ktuB (B:)
ifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkld
tgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqsl