PDB entry 5kt8

View 5kt8 on RCSB PDB site
Description: Crystal structure of the W139F variant of the catalase-peroxidase from B. pseudomallei treated with isoniazid
Class: oxidoreductase
Keywords: catalase, peroxidase, W139F, isoniazid, heme, OXIDOREDUCTASE
Deposited on 2016-07-11, released 2017-07-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Catalase-peroxidase
    Species: Burkholderia pseudomallei (strain 1710b) [TaxId:320372]
    Gene: katG, BURPS1710b_3366
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q3JNW6 (Start-727)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d5kt8a1, d5kt8a2
  • Chain 'B':
    Compound: Catalase-peroxidase
    Species: Burkholderia pseudomallei (strain 1710b) [TaxId:320372]
    Gene: katG, BURPS1710b_3366
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q3JNW6 (Start-727)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d5kt8b1, d5kt8b2
  • Heterogens: HEM, NA, CL, OXY, MPD, NIZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kt8A (A:)
msneakcpfhqaagngtsnrdwwpnqldlsilhrhsslsdpmgkdfnyaqafekldlaav
krdlhalmttsqdwwpadfghygglfirmawhsagtyrtadgrggagegqqrfaplnsfp
dnanldkarrllwpikqkygraiswadlliltgnvalesmgfktfgfaggradtwepedv
ywgsekiwlelsggpnsrysgdrqlenplaavqmgliyvnpegpdgnpdpvaaardirdt
farmamndeetvaliagghtfgkthgagpasnvgaepeaagieaqglgwksayrtgkgad
aitsglevtwtttptqwshnffenlfgyeweltkspagahqwvakgadavipdafdpskk
hrptmlttdlslrfdpayekisrrfhenpeqfadafarawfklthrdmgprarylgpevp
aevllwqdpipavdhplidaadaaelkakvlasgltvsqlvstawaaastfrgsdkrgga
ngarirlapqkdweanqpeqlaavletleairtafngaqrggkqvsladlivlagcagve
qaaknaghavtvpfapgradasqeqtdvesmavlepvadgfrnylkgkyrvpaevllvdk
aqlltlsapemtvllgglrvlganvgqsrhgvftareqaltndffvnlldmgtewkptaa
dadvfegrdratgelkwtgtrvdlvfgshsqlralaevygsadaqekfvrdfvavwnkvm
nldrfdla

    Sequence, based on observed residues (ATOM records): (download) 
    >5kt8A (A:)
gtsnrdwwpnqldlsilhrhsslsdpmgkdfnyaqafekldlaavkrdlhalmttsqdww
padfghygglfirmawhsagtyrtadgrggagegqqrfaplnsfpdnanldkarrllwpi
kqkygraiswadlliltgnvalesmgfktfgfaggradtwepedvywgsekiwlelsggp
nsrysgdrqlenplaavqmgliyvnpegpdgnpdpvaaardirdtfarmamndeetvali
agghtfgkthgagpasnvgaepeaagieaqglgwksayrtgkgadaitsglevtwtttpt
qwshnffenlfgyeweltkspagahqwvakgadavipdafdpskkhrptmlttdlslrfd
payekisrrfhenpeqfadafarawfklthrdmgprarylgpevpaevllwqdpipavdh
plidaadaaelkakvlasgltvsqlvstawaaastfrgsdkrggangarirlapqkdwea
nqpeqlaavletleairtafngaqrggkqvsladlivlagcagveqaaknaghavtvpfa
pgradasqeqtdvesmavlepvadgfrnylkgkyrvpaevllvdkaqlltlsapemtvll
gglrvlganvgqsrhgvftareqaltndffvnlldmgtewkptaadadvfegrdratgel
kwtgtrvdlvfgshsqlralaevygsadaqekfvrdfvavwnkvmnldrfdla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kt8B (B:)
msneakcpfhqaagngtsnrdwwpnqldlsilhrhsslsdpmgkdfnyaqafekldlaav
krdlhalmttsqdwwpadfghygglfirmawhsagtyrtadgrggagegqqrfaplnsfp
dnanldkarrllwpikqkygraiswadlliltgnvalesmgfktfgfaggradtwepedv
ywgsekiwlelsggpnsrysgdrqlenplaavqmgliyvnpegpdgnpdpvaaardirdt
farmamndeetvaliagghtfgkthgagpasnvgaepeaagieaqglgwksayrtgkgad
aitsglevtwtttptqwshnffenlfgyeweltkspagahqwvakgadavipdafdpskk
hrptmlttdlslrfdpayekisrrfhenpeqfadafarawfklthrdmgprarylgpevp
aevllwqdpipavdhplidaadaaelkakvlasgltvsqlvstawaaastfrgsdkrgga
ngarirlapqkdweanqpeqlaavletleairtafngaqrggkqvsladlivlagcagve
qaaknaghavtvpfapgradasqeqtdvesmavlepvadgfrnylkgkyrvpaevllvdk
aqlltlsapemtvllgglrvlganvgqsrhgvftareqaltndffvnlldmgtewkptaa
dadvfegrdratgelkwtgtrvdlvfgshsqlralaevygsadaqekfvrdfvavwnkvm
nldrfdla

    Sequence, based on observed residues (ATOM records): (download) 
    >5kt8B (B:)
gtsnrdwwpnqldlsilhrhsslsdpmgkdfnyaqafekldlaavkrdlhalmttsqdww
padfghygglfirmawhsagtyrtadgrggagegqqrfaplnsfpdnanldkarrllwpi
kqkygraiswadlliltgnvalesmgfktfgfaggradtwepedvywgsekiwlelsggp
nsrysgdrqlenplaavqmgliyvnpegpdgnpdpvaaardirdtfarmamndeetvali
agghtfgkthgagpasnvgaepeaagieaqglgwksayrtgkgadaitsglevtwtttpt
qwshnffenlfgyeweltkspagahqwvakgadavipdafdpskkhrptmlttdlslrfd
payekisrrfhenpeqfadafarawfklthrdmgprarylgpevpaevllwqdpipavdh
plidaadaaelkakvlasgltvsqlvstawaaastfrgsdkrggangarirlapqkdwea
nqpeqlaavletleairtafngaqrggkqvsladlivlagcagveqaaknaghavtvpfa
pgradasqeqtdvesmavlepvadgfrnylkgkyrvpaevllvdkaqlltlsapemtvll
gglrvlganvgqsrhgvftareqaltndffvnlldmgtewkptaadadvfegrdratgel
kwtgtrvdlvfgshsqlralaevygsadaqekfvrdfvavwnkvmnldrfdla