PDB entry 5ksx

View 5ksx on RCSB PDB site
Description: Crystal structure of human FPPS in complex with an allosteric inhibitor AM-02-072
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-07-10, released 2017-03-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'F':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ksxf_
  • Heterogens: PO4, 7AM, HOH

PDB Chain Sequences:

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5ksxF (F:)
    mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
    gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
    flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
    lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
    idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
    tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
    avflglarkiykrrk
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ksxF (F:)
    vyaqekqdfvqhfsqivrvlteghpeigdaiarlkevleynaiggkynrgltvvvafrel
    veprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaind
    anlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqnvdlvrftekr
    yksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdp
    svtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpa
    vflqyeedsyshimalieqyaaplppavflglarkiykr