PDB entry 5krs

View 5krs on RCSB PDB site
Description: HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid
Class: hydrolase, transferase/inhibitor
Keywords: HIV-1 Integrase Catalytic Core Domain, p75/LEDGF inhibitor, hydrolase, transferase-inhibitor complex
Deposited on 2016-07-07, released 2016-09-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-09-28, with a file datestamp of 2016-09-23.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q76353 (2-152)
      • expression tag (0-1)
      • engineered mutation (130)
    Domains in SCOPe 2.06: d5krsa1, d5krsa2
  • Heterogens: DMS, 6XI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5krsA (A:)
dsspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvh
tdngsnftsttvkaacwwagikqefgipynpqsqgviesmnkelkkiigqvrdqaehlkt
avqmavfihnkkrkggiggysagerivdiiatd

    Sequence, based on observed residues (ATOM records): (download) 
    >5krsA (A:)
dsspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvh
tdngsnftsttvkaacwwagikqefgipynpgviesmnkelkkiigqvrdqaehlktavq
mavfihnkkrkgggysagerivdiiatd