PDB entry 5kqf
View 5kqf on RCSB PDB site
Description: (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine (compound 12) bound to BACE1
Class: hydrolase/hydrolase inhibitor
Keywords: BACE-1, small molecule inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2016-07-06, released
2016-09-07
The last revision prior to the SCOPe 2.07 freeze date was dated
2016-10-05, with a file datestamp of
2016-09-30.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Beta-secretase 1
Species: Homo sapiens [TaxId:9606]
Gene: BACE1, BACE, KIAA1149
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d5kqfa_ - Heterogens: 6WD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5kqfA (A:)
masmtggqqmgrgsagvlpahgtqhgirlplrsglggaplglrlpretdeepeepgrrgs
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgynipqtdest
Sequence, based on observed residues (ATOM records): (download)
>5kqfA (A:)
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgvggsmiiggidhslytgslwyt
pirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksikaa
sstekfpdgfwlgeqlvcnifpvislylmgevtnqsfritilpqqylrpvdcykfaisqs
stgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaavegpfvtldmedcgyn