PDB entry 5kos

View 5kos on RCSB PDB site
Description: Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: protein-inhibitor complex, HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2016-07-01, released 2016-11-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-11-16, with a file datestamp of 2016-11-11.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Gene: REN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5kosa_
  • Chain 'B':
    Compound: renin
    Species: Homo sapiens [TaxId:9606]
    Gene: REN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5kosb_
  • Heterogens: NAG, 6VS, DMS, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kosA (A:)
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

    Sequence, based on observed residues (ATOM records): (download) 
    >5kosA (A:)
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsslggqivlggsdpqhye
gnfhyinliktgvwqiqmkgvsvgtllcedgclalvdtgasyisgstssieklmealgak
krlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdipppt
gptwalgatfirkfytefdrrnnrigfalar

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kosB (B:)
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

    Sequence, based on observed residues (ATOM records): (download) 
    >5kosB (B:)
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdslggqivlggsdpqhyeg
nfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealga
kkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippp
tgptwalgatfirkfytefdrrnnrigfalar