PDB entry 5kk7

View 5kk7 on RCSB PDB site
Description: Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase T688A mutant and Thio-disaccharide substrate analog complex
Class: hydrolase
Keywords: alpha/alpha-barrel, cation replacement, protein-glycan interaction, HYDROLASE
Deposited on 2016-06-21, released 2017-05-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
    Species: Homo sapiens [TaxId:9606]
    Gene: MAN1B1, UNQ747/PRO1477
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UKM7 (0-454)
      • engineered mutation (443)
    Domains in SCOPe 2.08: d5kk7a_
  • Chain 'B':
    Compound: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
    Species: Homo sapiens [TaxId:9606]
    Gene: MAN1B1, UNQ747/PRO1477
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UKM7 (0-454)
      • engineered mutation (443)
    Domains in SCOPe 2.08: d5kk7b_
  • Heterogens: CA, SO4, 1PS, BU1, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5kk7A (A:)
hlnyrqkgvidvflhawkgyrkfawghdelkpvsrsfsewfglgltlidaldtmwilglr
kefeearkwvskklhfekdvdvnlfestirilggllsayhlsgdslflrkaedfgnrlmp
afrtpskipysdvnigtgvahpprwtsdstvaevtsiqlefrelsrltgdkkfqeavekv
tqhihglsgkkdglvpmfinthsglfthlgvftlgaradsyyeyllkqwiqggkqetqll
edyveaiegvrthllrhsepskltfvgelahgrfsakmdhlvcflpgtlalgvyhglpas
hmelaqelmetcyqmnrqmetglspeivhfnlypqpgrrdvevkpadrhnllrpetvesl
fylyrvtgdrkyqdwgweilqsfsrftrvpsggyssinnvqdpqkpeprdkmesfflget
lkylfllfsddpnllsldayvfnaeahplpiwtpa

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5kk7B (B:)
hlnyrqkgvidvflhawkgyrkfawghdelkpvsrsfsewfglgltlidaldtmwilglr
kefeearkwvskklhfekdvdvnlfestirilggllsayhlsgdslflrkaedfgnrlmp
afrtpskipysdvnigtgvahpprwtsdstvaevtsiqlefrelsrltgdkkfqeavekv
tqhihglsgkkdglvpmfinthsglfthlgvftlgaradsyyeyllkqwiqggkqetqll
edyveaiegvrthllrhsepskltfvgelahgrfsakmdhlvcflpgtlalgvyhglpas
hmelaqelmetcyqmnrqmetglspeivhfnlypqpgrrdvevkpadrhnllrpetvesl
fylyrvtgdrkyqdwgweilqsfsrftrvpsggyssinnvqdpqkpeprdkmesfflget
lkylfllfsddpnllsldayvfnaeahplpiwtpa