PDB entry 5kcf

View 5kcf on RCSB PDB site
Description: crystal structure of the er-alpha ligand-binding domain (y537s) in complex with an n-ethyl, 4-methoxybenzyl obhs-n derivative
Deposited on 2016-06-06, released 2016-11-16
The last revision was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (239)
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (239)
  • Chain 'C':
    Compound: ncoa2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5KCF
  • Chain 'D':
    Compound: ncoa2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5KCF
  • Heterogens: OB5, OB4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.07, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >5kcfA (A:)
    ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
    inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
    vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
    vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
    dlllemldahrlhapts
    

    Sequence, based on observed residues (ATOM records):
    >5kcfA (A:)
    knslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwak
    rvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmv
    eifdmllatssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmaka
    gltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahrl
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >5kcfB (B:)
    ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
    inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
    vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
    vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
    dlllemldahrlhapts
    

    Sequence, based on observed residues (ATOM records):
    >5kcfB (B:)
    slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
    pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqmveifdmlla
    tssrfrmmnlqgeefvclksiillnsgvytflksleekdhihrvldkitdtlihlmakag
    ltlqqqhqrlaqlllilshirhmsnkgmehlysplsdlllemldahr
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >5kcfC (C:)
    khkilhrllqdsss
    

    Sequence, based on observed residues (ATOM records):
    >5kcfC (C:)
    kilhrllqd
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >5kcfD (D:)
    khkilhrllqdsss
    

    Sequence, based on observed residues (ATOM records):
    >5kcfD (D:)
    hkilhrllqd