PDB entry 5kby

View 5kby on RCSB PDB site
Description: Crystal structure of dipeptidyl peptidase IV in complex with SYR-472
Class: hydrolase/hydrolase inhibitor
Keywords: peptidase, glp-1, metabolic disease, co-complex, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2016-06-03, released 2016-07-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kbya1, d5kbya2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (12-739)
      • expression tag (7-11)
    Domains in SCOPe 2.08: d5kbyb1, d5kbyb2, d5kbyb3
  • Chain 'C':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kbyc1, d5kbyc2
  • Chain 'D':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5kbyd1, d5kbyd2
  • Heterogens: NAG, 6RL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kbyA (A:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5kbyA (A:)
rktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfdefghs
indysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvg
hklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngt
flayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtn
atsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclv
arqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgt
wevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsf
skeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilne
tkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgr
gsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlg
sgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyl
lihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikq
cfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kbyB (B:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5kbyB (B:)
hhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflens
tfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntq
wvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysa
lwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvnt
dslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydes
sgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkd
ctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnper
cqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskk
ldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteni
ivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsygg
yvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsrae
nfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiyt
hmshfikqcfslp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5kbyC (C:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5kbyC (C:)
rktytltdylkntyrlklyslrwisdheylyilvfnaeyvflentfdefghsindysisp
dgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvghklayvwn
ndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtflayaqfn
dtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtnatsiqita
pasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclvarqhiems
ttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtwevigiea
ltsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfskeakyyq
lrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnetkfwyqmi
lpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrgsgyqgdk
imhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgsgsgvfkc
giavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyllihgtadd
nvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqcfslp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5kbyD (D:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >5kbyD (D:)
rktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfdefghs
indysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvg
hklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngt
flayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtn
atsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclv
arqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgt
wevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsf
skeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilne
tkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgr
gsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlg
sgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyl
lihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikq
cfslp