PDB entry 5k65

View 5k65 on RCSB PDB site
Description: Crystal structure of VEGF binding IgG1-Fc (Fcab CT6)
Class: immune system
Keywords: Immune system, antibody engineering, immunoglobulin G1, Fc fragment, glycosylations, CH3 domain, Fcab, VEGF, vascular endothelial growth factor
Deposited on 2016-05-24, released 2017-09-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (134-136)
      • engineered mutation (163-164)
      • insertion (164)
      • insertion (164)
      • insertion (164)
      • insertion (164)
      • insertion (164)
      • engineered mutation (193-196)
      • engineered mutation (198-199)
      • engineered mutation (201-202)
      • engineered mutation (220)
      • engineered mutation (222-225)
    Domains in SCOPe 2.07: d5k65a1, d5k65a2
  • Chain 'B':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (134-136)
      • engineered mutation (163-164)
      • insertion (164)
      • insertion (164)
      • insertion (164)
      • insertion (164)
      • insertion (164)
      • engineered mutation (193-196)
      • engineered mutation (198-199)
      • engineered mutation (201-202)
      • engineered mutation (220)
      • engineered mutation (222-225)
    Domains in SCOPe 2.07: d5k65b1, d5k65b2
  • Heterogens: NAG, BMA, MAN, FUC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5k65A (A:)
tcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvev
hnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr
epqvytlppsrdelrfyqvsltclvkgfypsdiavewesngqpdifpnglnykttppvld
sdgsfflyskltvpypswlmgtrfscsvmhealhnhytqkhleyqwpt

    Sequence, based on observed residues (ATOM records): (download) 
    >5k65A (A:)
ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsr
delrfyqvsltclvkgfypsdiavewesngqpdifpnglnykttppvldsdgsfflyskl
tvpypswlmgtrfscsvmhealhnhytqkhleyqw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5k65B (B:)
tcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvev
hnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqpr
epqvytlppsrdelrfyqvsltclvkgfypsdiavewesngqpdifpnglnykttppvld
sdgsfflyskltvpypswlmgtrfscsvmhealhnhytqkhleyqwpt

    Sequence, based on observed residues (ATOM records): (download) 
    >5k65B (B:)
svflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqyns
tyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsrdel
rfyqvsltclvkgfypsdiavewesngqpdifpnglnykttppvldsdgsfflyskltvp
ypswlmgtrfscsvmhealhnhytqkhleyqw