PDB entry 5k4n

View 5k4n on RCSB PDB site
Description: Directed evolutionary changes in MBL super family - NDM-1 Round 10 crystal-2
Class: hydrolase
Keywords: Phosphatase, Directed evolution, MBL super family, NDM-1, HYDROLASE
Deposited on 2016-05-21, released 2017-04-26
Made obsolete on 2018-12-05

The last revision prior to the SCOPe 2.06 freeze date was dated 2017-04-26, with a file datestamp of 2017-04-21.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Metallo-beta-lactamase type 2
  Species: Klebsiella pneumoniae [TaxId:573]
  Gene: blaNDM-1
  Database cross-references and differences (RAF-indexed):
  • Uniprot C7C422 (Start-244)
    • engineered mutation (23)
    • engineered mutation (62)
    • engineered mutation (67)
    • engineered mutation (70)
    • engineered mutation (77)
    • engineered mutation (125)
    • engineered mutation (128)
    • engineered mutation (140)
    • engineered mutation (185)
    • engineered mutation (196-197)
    • engineered mutation (207)
    • engineered mutation (225)
  Domains in SCOPe 2.06: d5k4na_
• Heterogens: MES, MG, SV7, 6QV, ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >5k4nA (A:)
  ghmgeirptigqqmetgdqrfgdpvfrqlapnvwqhtsyldmpgfgavasnglivrdggr
  vlmvdtagtdaqtaqilkwikqeinlpvalavvthahqdkmggmdalhaagiatyanals
  nqlapregvvaaqhsltfaatgwvepatapnfgplkvfypgpghtsdnitvgidgtdiaf
  ggclirdskakslgnldeadtehyaasvrafgaafpkasmivmshfapdsraaithtarm
  adklr
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5k4nA (A:)
  dqrfgdpvfrqlapnvwqhtsyldmpgfgavasnglivrdggrvlmvdtagtdaqtaqil
  kwikqeinlpvalavvthahqdkmggmdalhaagiatyanalsnqlapregvvaaqhslt
  faatgwvepatapnfgplkvfypgpghtsdnitvgidgtdiafggclirdskakslgnld
  eadtehyaasvrafgaafpkasmivmshfapdsraaithtarmadklr