PDB entry 5jzi

View 5jzi on RCSB PDB site
Description: crystal structure of 1406 tcr bound to hla-a2 with hcv 1406-1415 antigen peptide
Deposited on 2016-05-16, released 2017-05-31
The last revision was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
  • Chain 'C':
    Compound: KLV peptide
    Species: Hepatitis C virus, synthetic [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JZI (0-9)
  • Chain 'D':
    Compound: HCV1406 TCR alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JZI (0-End)
  • Chain 'E':
    Compound: HCV1406 TCR beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JZI
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
  • Chain 'H':
    Compound: KLV peptide
    Species: Hepatitis C virus, synthetic [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JZI (0-9)
  • Chain 'I':
    Compound: HCV1406 TCR alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JZI (0-End)
  • Chain 'J':
    Compound: HCV1406 TCR beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JZI (Start-244)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.07, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >5jziA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

    Sequence, based on observed residues (ATOM records):
    >5jziA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavdheatlrcwalsfypaeilwqredqtqdtevetrpagdgtfqkwav
    vvpsgqeytchqheglpltl
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >5jziB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records):
    >5jziB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyytetptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >5jziC (C:)
    klvalginav
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >5jziD (D:)
    mefsmaqtvtqsqpemsvqeaetvtlsctydtsesdyylfwykqppsrqmilvirqeayk
    qqnatenrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniq
    npdpavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsav
    awsnksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records):
    >5jziD (D:)
    mefsmaqtvtqsqpemsvqeaetvtlsctydtsesdyylfwykqppsrqmilvirqeayk
    qqnaenrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniqn
    pdpavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsava
    wsnksdfacanafnnsiipedtffpsp
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >5jziE (E:)
    mdlmeadiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnste
    kgdlssestvsrirtehfpltlesarpshtsqylcasrrgpyeqyfgpgtrltvtedlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryclssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records):
    >5jziE (E:)
    eadiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnstekgdl
    ssestvsrirtehfpltlesarpshtsqylcasrrgpyeqyfgpgtrltvtedlknvfpp
    evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpal
    ndsryclssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >5jziF (F:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

    Sequence, based on observed residues (ATOM records):
    >5jziF (F:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rdapkththhsdheatlrcwalsfypaeitltwqrdedqtqtlvetrpagdgtfqkwagq
    eqrytchvqheglpkpltlrwe
    

  • Chain 'G':
    Sequence, based on SEQRES records:
    >5jziG (G:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records):
    >5jziG (G:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdecrvnhvtlsqpkivkwdrdm
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >5jziH (H:)
    klvalginav
    

  • Chain 'I':
    Sequence, based on SEQRES records:
    >5jziI (I:)
    mefsmaqtvtqsqpemsvqeaetvtlsctydtsesdyylfwykqppsrqmilvirqeayk
    qqnatenrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniq
    npdpavyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsav
    awsnksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records):
    >5jziI (I:)
    mefsmaqtvtqsqpemsvqeaetvtlsctydtsesdyylfwykqppsrqmilvirqeayk
    qqnatenrfsvnfqkaaksfslkisdsqlgdaamyfcaygeddkiifgkgtrlhilpniq
    npdpavyqlrdsksdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsava
    wsnksdfacanafnnsiipedtffpsp
    

  • Chain 'J':
    Sequence, based on SEQRES records:
    >5jziJ (J:)
    mdlmeadiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnste
    kgdlssestvsrirtehfpltlesarpshtsqylcasrrgpyeqyfgpgtrltvtedlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryclssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records):
    >5jziJ (J:)
    eadiyqtprylvigtgkkitlecsqtmghdkmywyqqdpgmelhlihysygvnstekgdl
    ssestvsrirtehfpltlesarpshtsqylcasrrgpyeqyfgpgtrltvtedlknvfpp
    evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpal
    ndsryclssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
    d