PDB entry 5jwl

View 5jwl on RCSB PDB site
Description: Factor Inhibiting HIF D201E in Complex with Zn, and Alpha-Ketoglutarate
Class: oxidoreductase
Keywords: Hypoxia Inducible Factor, Factor Inhibiting HIF, Oxygenase, Oxygen Sensing, OXIDOREDUCTASE
Deposited on 2016-05-12, released 2017-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hypoxia-inducible factor 1-alpha inhibitor
    Species: Homo sapiens [TaxId:9606]
    Gene: HIF1AN, FIH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWT6 (Start-351)
      • engineered mutation (203)
    Domains in SCOPe 2.08: d5jwla_
  • Heterogens: AKG, PEG, ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jwlA (A:)
gshmaataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelie
neepvvltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkpr
snreemkfhefveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkr
gwgqltsnllligmegnvtpahyeeqqnffaqikgykrcilfppdqfeclypypvhhpcd
rqsqvdfdnpdyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwy
kgaptpkrieyplkahqkvaimrniekmlgealgnpqevgpllntmikgryn

    Sequence, based on observed residues (ATOM records): (download) 
    >5jwlA (A:)
vasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdtn
lvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhef
veklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnlll
igmegnvtpahyeeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnpd
yerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkriey
plkahqkvaimrniekmlgealgnpqevgpllntmikgryn