PDB entry 5jmy

View 5jmy on RCSB PDB site
Description: neprilysin complexed with lbq657
Class: hydrolase
Keywords: HYDROLASE, LBQ657, sacubitril, heart failure
Deposited on 2016-04-29, released 2016-06-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neprilysin
    Species: Homo sapiens [TaxId:9606]
    Gene: MME, EPN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5jmya_
  • Chain 'B':
    Compound: Neprilysin
    Species: Homo sapiens [TaxId:9606]
    Gene: MME, EPN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5jmyb_
  • Heterogens: NAG, ZN, 6LD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jmyA (A:)
ddgickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrd
elevvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvate
nweqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyy
ectgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakped
rndpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyl
tklkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrca
nyvngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeek
alaikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdk
dewisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfdd
ngrnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadn
gglgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvh
spgnfriigtlqnsaefseafhcrknsymnpekkcrvw

    Sequence, based on observed residues (ATOM records): (download) 
    >5jmyA (A:)
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5jmyB (B:)
ddgickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrd
elevvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvate
nweqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyy
ectgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakped
rndpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyl
tklkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrca
nyvngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeek
alaikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdk
dewisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfdd
ngrnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadn
gglgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvh
spgnfriigtlqnsaefseafhcrknsymnpekkcrvw

    Sequence, based on observed residues (ATOM records): (download) 
    >5jmyB (B:)
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw