PDB entry 5jlv

View 5jlv on RCSB PDB site
Description: Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C
Class: hydrolase
Keywords: glycosylation, botulinum neurotoxin, receptor binding domain, HYDROLASE
Deposited on 2016-04-27, released 2016-06-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-06-15, with a file datestamp of 2016-06-10.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Botulinum neurotoxin type A
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10845 (3-427)
      • expression tag (1-2)
      • engineered mutation (289)
    Domains in SCOPe 2.06: d5jlva1, d5jlva2, d5jlva3
  • Chain 'B':
    Compound: Botulinum neurotoxin type A
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10845 (3-427)
      • expression tag (1-2)
      • engineered mutation (289)
    Domains in SCOPe 2.06: d5jlvb1, d5jlvb2, d5jlvb3
  • Chain 'C':
    Compound: Synaptic vesicle glycoprotein 2C
    Species: Homo sapiens [TaxId:9606]
    Gene: SV2C, KIAA1054
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q496J9 (22-End)
      • expression tag (19-21)
  • Chain 'D':
    Compound: Synaptic vesicle glycoprotein 2C
    Species: Homo sapiens [TaxId:9606]
    Gene: SV2C, KIAA1054
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ACT, PO4, FUC, NAG, BMA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jlvA (A:)
gpmniintsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievil
knaivynsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlq
dtqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgnih
asnnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqyd
kpyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgakfiikkyasg
nkdnivrnndrvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmksknd
qgitnkckmnlqdnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvd
dgwgerpl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jlvA (A:)
pmniintsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievilk
naivynsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlqd
tqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgniha
snnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqydk
pyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgakfiikkyankd
nivrnndrvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmkskndqgi
tnkckmnlqdnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvddgw
gerpl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5jlvB (B:)
gpmniintsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievil
knaivynsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlq
dtqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgnih
asnnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqyd
kpyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgakfiikkyasg
nkdnivrnndrvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmksknd
qgitnkckmnlqdnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvd
dgwgerpl

    Sequence, based on observed residues (ATOM records): (download) 
    >5jlvB (B:)
pmniintsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievilk
naivynsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlqd
tqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgniha
snnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqydk
pyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgakfiikkyankd
nivrnndrvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmkskndqgi
tnkckmnlqdnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvddgw
gerpl

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.