PDB entry 5jkg

View 5jkg on RCSB PDB site
Description: The crystal structure of FGFR4 kinase domain in complex with LY2874455
Class: transferase/transferase inhibitor
Keywords: Kinase, Small-molecule Inhibitor, ATP binding pocket, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-04-26, released 2016-10-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-10-05, with a file datestamp of 2016-09-30.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 4
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR4, JTK2, TKF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22455
      • conflict (34)
    Domains in SCOPe 2.08: d5jkga_
  • Heterogens: 6LF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jkgA (A:)
gpllaglvsldlpldplwefprdrlvlgkplgegafgqvvraeafgmdparpdqastvav
kmlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlrefl
rarrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvte
dnvmkiadfglargvhhidyykktsngrlpvkwmapealfdrvythqsdvwsfgillwei
ftlggspypgipveelfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvea
ldkvllavsee

    Sequence, based on observed residues (ATOM records): (download) 
    >5jkgA (A:)
dlpldplwefprdrlvlgkplgegafgqvvraeafgmdparpdqastvavkmlkddkdla
dlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflrarrppgpplsfp
vlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfgllpvkwmapealfdr
vythqsdvwsfgillweiftlggspypgipveelfsllreghrmdrpphcppelyglmre
cwhaapsqrptfkqlvealdkvllav