PDB entry 5jhg

View 5jhg on RCSB PDB site
Description: Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11
Class: signaling protein/transcription
Keywords: RhoA-ARHRhoGEF11 complex, target-based pharmaceutical design, SIGNALING PROTEIN-TRANSCRIPTION complex
Deposited on 2016-04-21, released 2017-04-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-04-26, with a file datestamp of 2017-04-21.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5jhga1, d5jhga2
  • Chain 'B':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5jhgb_
  • Chain 'E':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5jhge1, d5jhge2
  • Chain 'F':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5jhgf_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jhgA (A:)
mqnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpr
eelarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqf
csyqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesi
ikhteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpl
aaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchskta
vgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwme
lleeavrna

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhgA (A:)
qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchtfspv
lklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5jhgB (B:)
maairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdt
agqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
lrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
a

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhgB (B:)
airkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5jhgE (E:)
mqnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpr
eelarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqf
csyqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesi
ikhteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpl
aaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchskta
vgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwme
lleeavrna

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhgE (E:)
qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktfs
pvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5jhgF (F:)
maairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdt
agqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
lrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
a

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhgF (F:)
airkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq