PDB entry 5jh3

View 5jh3 on RCSB PDB site
Description: Human cathepsin K mutant C25S
Class: hydrolase
Keywords: allostery cysteine, peptidase proteolysis, enzyme regulation, collagenase, hydrolase
Deposited on 2016-04-20, released 2016-11-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-01-11, with a file datestamp of 2017-01-06.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin k
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSK, CTSO, CTSO2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43235 (Start-222)
      • engineered mutation (32)
    Domains in SCOPe 2.08: d5jh3a_
  • Heterogens: SO4, ACT, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jh3A (A:)
yipewegrapdsvdyrkkgyvtpvknqgqcgsswafssvgalegqlkkktgkllnlspqn
lvdcvsendgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyre
ipegnekalkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiq
kgnkhwiiknswgenwgnkgyilmarnknnacgianlasfpkm

    Sequence, based on observed residues (ATOM records): (download) 
    >5jh3A (A:)
pdsvdyrkkgyvtpvknqgqcgsswafssvgalegqlkkktgkllnlspqnlvdcvsend
gcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegnekal
kravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwiik
nswgenwgnkgyilmarnknnacgianlasfpkm