PDB entry 5j9y

View 5j9y on RCSB PDB site
Description: EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b
Class: transferase
Keywords: tyrosine kinase, covalent inhibitor, drug resistance, transferase
Deposited on 2016-04-11, released 2016-08-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-09-07, with a file datestamp of 2016-09-02.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (0-322)
      • conflict (93)
    Domains in SCOPe 2.07: d5j9ya_
  • Heterogens: 6HL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5j9yA (A:)
    eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
    keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
    wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
    pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
    pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
    fyralmdeedmddvvdadeylip
    

    Sequence, based on observed residues (ATOM records): (download)
    >5j9yA (A:)
    eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
    keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
    wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllekeyhaeggkvpik
    wmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppic
    tidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdedmddvvdadeylip