PDB entry 5j7g

View 5j7g on RCSB PDB site
Description: Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.
Class: ligase
Keywords: p53, MDM2, MDMX, protein-protein interaction, cancer, inhibitor, ligase
Deposited on 2016-04-06, released 2017-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5j7ga1, d5j7ga2
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5j7gb_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5j7gc_
  • Chain 'D':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d5j7gd_
  • Heterogens: 6GG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5j7gA (A:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >5j7gA (A:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5j7gB (B:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >5j7gB (B:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5j7gC (C:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >5j7gC (C:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5j7gD (D:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen

    Sequence, based on observed residues (ATOM records): (download) 
    >5j7gD (D:)
mqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvn